There are no differences between handling a mini, midi or maxi edit in Premiere if you don't understand the basics of a well-organized workflow...
1. Your project organization starts on the hard drive where you populate your project folder with the right sub-folder structure (ex: Project folder, footage folder, audio folder, output folder etc.)
2. Copy your footage in the proper folder, so you don't make a mess if you're moving or archiving the project
3. Check your footage. All the files have the same codec? Does it need to be transcoded? Are you sure you want to edit with 4k files instead of creating proxies?
4. NOW Open Premiere and re-create the same project folder structure you have on your hard drive. Assigning different folders for auto-save and render files can be a good choice :)
5. Import your audio/video files (dragging or with the double-click-import-way) and place them in the right folders
6. Open and WATCH EVERY SINGLE SHOT, divide them in subfolders by context (ex: park shots, sea shots etc.) or scene (ex: Sh01 folder with 01_01, 01_02, 01_03... takes) and name the folder in a clear useful way (ex: "01//LS Mark running in the park " where "01" is the scene number "LS" describes the framing - Long Shot + description "Mark running in the park") use the comment column to take additional notes (ex: best acting or wrong continuity...), use the labels to mark it as good/alternative/useless so you have a visual cue of your best picks (TIP: Try to assign 1,2,3, shortcuts to the labels in the keyboard customization panel.).
7. Now mark IN and OUT of every shot and make a "selection" timeline so you can watch different takes of every shot one after another and pick the best one. Use extended markers in this selection timeline to have a visual reference of where-is-what (TIP: The markers panel of Premiere is a real hero here!).
8. AFTER you've organized your footage on your hard drive, transcoded (if necessary), imported, watched, marked and selected NOW you can start editing.
This is how you conquer a "massive" edit in Premiere Pro. Dragging your footage and place IN and OUTs on the timeline makes your project a giant mess...