I've been using a Logitech M570 trackball for a couple of years now and I never get tired when using that type of mouse (or is it mice? Maybe just trackballs?) for editing.
Yeah, I know it can be difficult to adjust to the fact that instead of using your hand/arm to move the cursor around you now have to use your thumb instead - I've encountered many funny reactions from fellow filmmakers who couldn't get their head around it and angrily discarded the trackball as being faulty or useless :P
I find it to be a lot more natural and relaxed to use a trackball than an ordinary mouse, especially since your fingers aren't moving around as much as with a mouse, so perhaps you should try looking down that road and see if it's something for you?
It's called a parallax effect and is created by cutting different elements out of a still image in photoshop and placing them on different layers.
You then import these layers into after effects and alter their scale and distance from each other, using a camera with very subtle movement to achieve parallax between foreground and background objects.
Her hand moving slightly was probably done with the puppet tool in after effects.
Do a youtube search for "2.5D after effects" or "parallax effect after effects" and you'll find lots of detailed tutorials :)
Shut up and take my money!
DNxHD all the way!