Spike Jonze seems to be trying really hard to be Chris Cunningham in this ad, and failing at it.
It sounds like a good idea, but it's best to use modifiers so you're not picking your hands up off of the board as much. Set your shortcuts around the natural position your hand or hands rest on the board. You'll likely have 1 hand on the mouse and other other on the board most of the day. Single keystrokes would mean you'd have to slide around the board a great deal more. Hitting keys like CRTL+SHIFT+A to de-select all tracks before placing an edit (Avid) become almost like playing an instrument - it's muscle memory and once you know them you won't even have to look at your keyboard while working. Kinda like typing using Qwerty.