We're talking Martin Scorsese, David Fincher, Peter Jackson, Quentin Tarantino, Steve McQueen, Lone Scherfig, and David Cronenberg just to name a few. The video below is a compilation of Film4 interviews. 

The decades of experience these directors have cumulatively is astounding (I'm lazy and I'm not going to do the math). They have so much wisdom to impart -- and in this particular video they provide plenty of gems to mull over until the foreseeable future. However, the thing that stuck out the most to me was something that director Lone Scherfig said, which was simply to be courageous. 

As filmmakers, there are plenty of opportunities for our spirit and resolve to be diminished by those that wish to diminish it -- the culprit usually tends to be ourselves -- but for the sake of our family, friends, ourselves, the project we're working on -- we have to be able to be courageous enough to let go of perfection and embrace "what works". Oftentimes, it's "what works" that gives our projects the life and humanity that makes them relatable and enjoyable to our audience -- and later on, ourselves.

Source: Film4